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Scientist, Chemistry

Company: Maureen Kube Consulting
Location: Jupiter
Posted on: December 23, 2018

Job Description:

Expansion Therapeutics is a drug discovery and development company pursuing the vast potential of small molecule medicines for RNA---mediated diseases. We are initially focused on expansion repeat disorders, a set of -30 genetic diseases for which there are no satisfactory therapies. Our lead disease focus, myotonic dystrophy type 1 (DM1), is the most frequent cause of adult onset muscular dystrophy. Expansion has assembled an initial focused pipeline of compositions targeting repeats that drive a number of expansion repeat disorders. Summary Perform research in the laboratory as a synthetic and medicinal chemist applying the latest knowledge and techniques in the field. Advance the assigned program and contribute to the identification of a lead or development candidate. Essential Functions --- Design and execute syntheses of complex organic molecules on a milligram to multi-gram scale --- Use advanced laboratory techniques to purify mixtures of compounds --- Use state of the art techniques to characterize intermediates and final compounds --- Rationally design a series of target molecules for a pharmacological target of interest --- Use medicinal chemistry tools and techniques to plan and design synthetic targets --- Communicate results to co-workers and management in both oral and written manner and assist in the preparation of patent applications Qualifications --- Ph.D. in synthetic organic chemistry strongly preferred; a combination of relevant education and applicable job experience may be considered --- 1-2 years of post-graduate experience working in the biotechnology or pharmaceutical industry or a related position as a laboratory scientist --- Highly proficient in advanced synthetic, purification and spectroscopic techniques utilized in the preparation and characterization of complex organic molecules --- Demonstrated ability to design synthetic targets and successfully execute their syntheses --- Several first author or co-author publications in peer-reviewed journals demonstrating research accomplishments is preferred --- Familiarity with Structure-Based Drug Design --- Firm understanding of modern Medicinal Chemistry concepts and the ability to use them in the design of target molecules or to improve the properties of existing compounds --- Ability to work effectively in teams and collaborate with other scientists including microbiologists, structural biologists, pharmacologists and toxicologists --- Self-starter with a strong work ethic and ability to work independently and show flexibility when needed --- Effective oral and written English communication skills --- Familiarity with standard laboratory instrumentation, computers, and office and laboratory software

Keywords: Maureen Kube Consulting, Jupiter , Scientist, Chemistry, Other , Jupiter, Florida

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